TOMM70 Gene Summary [Human]
This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. The protein interacts with the SARS-CoV and SARS-Cov-2 ORF9b proteins. [provided by RefSeq, Dec 2021]
Details
| Type | Protein Coding |
| Official Symbol | TOMM70 |
| Official Name | translocase of outer mitochondrial membrane 70 [Source:HGNC Symbol;Acc:HGNC:11985] |
| Ensembl ID | ENSG00000154174 |
| Bio databases IDs | |
| Aliases | translocase of outer mitochondrial membrane 70, Mitochondrial import receptor subunit TOM70 |
| Synonyms | 2610044B22Rik, D16Ium22, D16Ium22e, D16Wsu109e, mKIAA0719, TOM70, TOM70A, TOMM70A, translocase of outer mitochondrial membrane 70, translocase of outer mitochondrial membrane 70A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TOMM70 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein carrier
- TPR repeat
- cytoplasmic domain
- Tetratricopeptide repeats
- mitochondrial import receptor subunit TOM70
- protein binding
- tetratricopeptide repeat
- signal sequence binding
- transporter
Pathways
Biological processes and signaling networks where the TOMM70 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Mitochondria
- mitochondrial membrane
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TOMM70 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to mitochondrion
- protein import into mitochondrial outer membrane
- response to thyroxine stimulus
- protein import into mitochondrial matrix
- negative regulation of cell growth involved in cardiac muscle cell development
- activation of innate immune response
- positive regulation of interferon-beta production
- protein import into mitochondrial inner membrane
- regulation of apoptotic process
- positive regulation of defense response to virus by host
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- mitochondrial membrane
- mitochondrion
- membrane
- mitochondrial outer membrane
- mitochondrial outer membrane translocase complex
Molecular Function
What the gene product does at the molecular level
- mitochondrion targeting sequence binding
- protein binding
- protein transmembrane transporter activity
- binding, bridging