BTG3 Gene Summary [Human]
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Details
| Type | Protein Coding |
| Official Symbol | BTG3 |
| Official Name | BTG anti-proliferation factor 3 [Source:HGNC Symbol;Acc:HGNC:1132] |
| Ensembl ID | ENSG00000154640 |
| Bio databases IDs | |
| Aliases | BTG anti-proliferation factor 3 |
| Synonyms | ANA, ANA/BTG3, APRO4, BTG anti-proliferation factor 3, TOB5, TOB55, TOFA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BTG3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BTG family
- protein binding
- proline rich domain
- tob/btg1 family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- liver cancer
- hepatocellular carcinoma
- lung cancer
- diabetic ketoacidosis
- prostate cancer
- organismal death
- Marfan syndrome
- thoracic cancer
role in cell
- binding in
- phosphorylation in
- proliferation
- expression in
- cell death
- cell cycle progression
- activation in
- differentiation
- binding
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BTG3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- negative regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding