FGF19
FGF19 Gene Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FGF19 |
| Official Name | fibroblast growth factor 19 [Source:HGNC Symbol;Acc:HGNC:3675] |
| Ensembl ID | ENSG00000162344 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 19 |
| Synonyms | Fgf15,Fgf8a,fibroblast growth factor 15,fibroblast growth factor 19 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- protein binding
- fibroblast growth factor receptor binding
- growth factor
Pathways
Biological processes and signaling networks where the FGF19 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- FGFR4
- KLB
- FGFR3
- heparin
- RXRA
- FGFR1
- UBR3
- NR1H4
- NPTXR
- THSD4
disease
- weight loss
- neoplasia
- dysplasia
- metastasis
- epithelial cancer
- obesity
- weight gain
- diabetes mellitus
- hepatocellular carcinoma
- liver cancer
regulated by
- ODC1
- Immunoglobulin
- MALRD1
- NR1H4
- beta-estradiol
- FOXA2
- FXR/RXRα/FXR ligand/retinoic acid
- SORL1
- NR5A2
- TLR7
regulates
- LCN2
- lipid
- CTNNB1
- AKT
- CXCL8
- IL6
- IL1B
- cholesterol
- STAT3
- Cxcl1
role in cell
- production in
- apoptosis
- cell viability
- number
- expression in
- migration
- proliferation
- invasion
- growth
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the FGF19 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of bile acid biosynthetic process
- positive regulation of cell proliferation
- nervous system development
- positive regulation of glucose import
- fibroblast growth factor receptor signaling pathway
- positive regulation of MAPK cascade
- organ morphogenesis
- negative regulation of gene expression
- positive regulation of JNK cascade
- positive regulation of gene expression
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- cell differentiation
- regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- growth factor activity
- protein binding
- fibroblast growth factor receptor binding