PSD3 Gene Summary [Human]
Predicted to enable guanyl-nucleotide exchange factor activity and phospholipid binding activity. Predicted to be involved in regulation of ARF protein signal transduction and regulation of catalytic activity. Predicted to be located in membrane. Predicted to be active in ruffle membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PSD3 |
| Official Name | pleckstrin and Sec7 domain containing 3 [Source:HGNC Symbol;Acc:HGNC:19093] |
| Ensembl ID | ENSG00000156011 |
| Bio databases IDs | |
| Aliases | pleckstrin and Sec7 domain containing 3 |
| Synonyms | 4931420C21Rik, D430018P08, DKFZP761K1423, EFA6D, EFA6R, HCA67, pleckstrin and Sec7 domain containing 3, RGD1559968 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSD3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sec7
- Sec7 domain
- guanyl-nucleotide exchange factor
- PH domain
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- Alzheimer disease
- breast cancer
- schizophrenia
- dementia
- prostate cancer
- coronary artery disease
- keratoconus
- systemic lupus erythematosus
- insulin-dependent diabetes mellitus
role in cell
- expression in
- migration
- invasion by
- GTP loading in
- loss
- loss in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- cellular membrane
- cell cortex
- Plasma Membrane
- membrane ruffles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSD3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of ARF protein signal transduction
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- ruffle membrane
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity