PLSCR1 Gene Summary [Human]
This gene encodes a phospholipid scramblase family member. The encoded protein is involved in disruption of the asymmetrical distribution of phospholipids between the inner and outer leaflets of the plasma membrane, resulting in externalization of phosphatidylserine. This cell membrane disruption plays an important role in the blood coagulation cascade as well as macrophage clearing of apoptotic cells. The encoded protein has additionally been implicated in gene regulation and interferon-induced antiviral responses. [provided by RefSeq, May 2022]
Details
| Type | Protein Coding |
| Official Symbol | PLSCR1 |
| Official Name | phospholipid scramblase 1 [Source:HGNC Symbol;Acc:HGNC:9092] |
| Ensembl ID | ENSG00000188313 |
| Bio databases IDs | |
| Aliases | phospholipid scramblase 1 |
| Synonyms | HMMTRA1B, MMTRA1B, Phospholipid scramblase 1, PLSCR, PL scramblase 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLSCR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- palmitoylation site
- viral receptor
- nuclease
- epidermal growth factor receptor binding
- nuclear localization sequence
- calcium ion binding
- metal ion binding
- enzyme binding
- protein binding
- magnesium ion binding
- SH3-domain binding
- LURP-one-related
- CD4 receptor binding
- zinc ion binding
- phospholipid scramblase
- mercury ion binding
- PXXP motif
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- critical COVID-19
- COVID-19
- psoriasis
- delayed hypersensitive reaction
- systemic lupus erythematosus
- mucopolysaccharidosis type IVB
- Behcet disease
- systemic autoimmune syndrome
- acne
role in cell
- expression in
- apoptosis
- cell death
- survival
- G1 phase
- binding in
- differentiation
- transactivation in
- proliferation
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-soluble membrane fractions
- Cytoplasm
- perinuclear Golgi regions
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- Golgi Apparatus
- cytosol
- nucleoplasm
- nucleoli
- secretory vesicles
- specific granules
- tertiary granules
- extracellular matrix
- membrane rafts
- detergent insoluble microdomains
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLSCR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
- positive regulation of transcription from RNA polymerase II promoter
- acute-phase response
- regulation of Fc receptor mediated stimulatory signaling pathway
- phosphatidylserine biosynthetic process
- positive regulation of innate immune response
- phosphatidylserine exposure on apoptotic cell surface
- positive regulation of gene expression
- apoptotic process
- phospholipid scrambling
- defense response to virus
- regulation of mast cell activation
- response to lead ion
- platelet activation
- negative regulation of viral genome replication
- response to interferon-beta
- negative regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cytoplasm
- membrane
- membrane raft
- cytosol
- Golgi apparatus
- nucleolus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- lead ion binding
- CD4 receptor binding
- epidermal growth factor receptor binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- magnesium ion binding
- DNA binding
- protein binding
- calcium ion binding
- mercury ion binding
- nuclease activity
- viral receptor activity
- SH3 domain binding
- phospholipid scramblase activity
- enzyme binding