TRIM63 Gene Summary [Human]
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]
Details
| Type | Protein Coding |
| Official Symbol | TRIM63 |
| Official Name | tripartite motif containing 63 [Source:HGNC Symbol;Acc:HGNC:16007] |
| Ensembl ID | ENSG00000158022 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 63, muscle-specific RING finger protein 1, iris ring finger protein, striated muscle RING zinc finger protein |
| Synonyms | IRF, Murf, MURF1, MURF2, Muscle-specific ring finger protein 1, RF1, RNF28, SMRZ, tripartite motif-containing 63 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM63 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- B-Box C-terminal domain
- ubiquitin protein ligase activity
- enzyme
- Ring finger domain
- protein binding
- B-box-type zinc finger superfamily
- cytoskeletal protein binding
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- Titin binding domain
- B-box zinc finger
Pathways
Biological processes and signaling networks where the TRIM63 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pulmonary edema
- cardiac hypertrophy
- hereditary disorder
- weight gain
- myopathy
- hypertrophic cardiomyopathy
- bleeding
- Ullrich congenital muscular dystrophy
regulated by
- D-glucose
- cisplatin
- quercetin
- FOXO1:NR3C1:(ALDO,11DCORST,CORST,CORT):TRIM63 gene
- epinephrine
- testosterone propionate
- dexamethasone
- HSP70
- AZGP1
- ERK1/2
role in cell
- ubiquitination in
- formation
- degradation in
- quantity
- structural integrity
- size
- atrophy
- abnormal morphology
- glycolysis in
- contractility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- myofibrils
- m-bands
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM63 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cardiac muscle hypertrophy
- signal transduction
- muscle contraction
- response to glucocorticoid stimulus
- response to interleukin-1
- negative regulation of glycolysis
- response to electrical stimulus involved in regulation of muscle adaptation
- skeletal muscle atrophy
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- Z disc
- nucleus
- cytoplasm
- M band
- microtubule
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- titin binding