RNF207 Gene Summary [Human]
Enables Hsp70 protein binding activity; chaperone binding activity; and transmembrane transporter binding activity. Involved in positive regulation of delayed rectifier potassium channel activity; positive regulation of gene expression; and positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | RNF207 |
| Official Name | ring finger protein 207 [Source:HGNC Symbol;Acc:HGNC:32947] |
| Ensembl ID | ENSG00000158286 |
| Bio databases IDs | |
| Aliases | ring finger protein 207, OTTHUMG00000001089 |
| Synonyms | C1orf188, D330010C22Rik, Gm143, LOC100128518, ring finger protein 207 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF207 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- Hsp70 protein binding
- B-Box C-terminal domain
- protein binding
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ion channel binding
- B-box zinc finger
- chaperone binding
- zinc-RING finger domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- perinuclear region
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF207 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of gene expression
- cell-cell signaling involved in cardiac conduction
- regulation of cardiac muscle contraction
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- chaperone binding
- ion channel binding
- Hsp70 protein binding