TAGLN2 Gene Summary [Human]
The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]
Details
| Type | Protein Coding |
| Official Symbol | TAGLN2 |
| Official Name | transgelin 2 [Source:HGNC Symbol;Acc:HGNC:11554] |
| Ensembl ID | ENSG00000158710 |
| Bio databases IDs | |
| Aliases | transgelin 2, SM22-alpha homolog |
| Synonyms | 2700094C18Rik, HA1756, Sm22a, Sm22B, SM22beta, transgelin 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAGLN2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calponin homology domain
- Calponin family repeat
- calponin homology (CH) domain superfamily
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- systemic lupus erythematosus
- colorectal cancer
- preeclampsia
- COVID-19
- organismal death
- essential thrombocythemia
- infection by HIV-1
role in cell
- apoptosis
- activation in
- proliferation
- differentiation
- function
- migration
- phosphorylation in
- motility
- invasion
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cytosol
- pseudopodia
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAGLN2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- actin filament organization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- actin cytoskeleton
- vesicle
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- cadherin binding