Tagln2 Gene Summary [Mouse]
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and epithelial cell differentiation. Predicted to be active in actin cytoskeleton. Is expressed in several structures, including autopod; cardiovascular system; gut; hemolymphoid system gland; and telencephalon ventricular layer. Orthologous to human TAGLN2 (transgelin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Tagln2 |
| Official Name | transgelin 2 [Source:MGI Symbol;Acc:MGI:1312985] |
| Ensembl ID | ENSMUSG00000026547 |
| Bio databases IDs | |
| Aliases | transgelin 2 |
| Synonyms | 2700094C18Rik, HA1756, Sm22a, Sm22B, SM22beta, transgelin 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tagln2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calponin homology domain
- Calponin family repeat
- calponin homology (CH) domain superfamily
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- systemic lupus erythematosus
- colorectal cancer
- preeclampsia
- COVID-19
- organismal death
- essential thrombocythemia
- infection by HIV-1
regulates
- actin
- F Actin
- fatty acid
- RAS homolog
- FABP5
- MLC
role in cell
- apoptosis
- activation in
- proliferation
- differentiation
- function
- migration
- phosphorylation in
- motility
- invasion
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cytosol
- pseudopodia
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tagln2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- actin filament organization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- actin cytoskeleton
- vesicle
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- cadherin binding