SLAMF8 Gene Summary [Human]
This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SLAMF8 |
| Official Name | SLAM family member 8 [Source:HGNC Symbol;Acc:HGNC:21391] |
| Ensembl ID | ENSG00000158714 |
| Bio databases IDs | |
| Aliases | SLAM family member 8 |
| Synonyms | 5830408F06Rik, BLAME, CD353, LOC100048553, SBBI42, SLAM family member 8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLAMF8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Crohn disease
- nasal type extranodal NK-/T-cell lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- natural killer cell neoplasia
- ulcerative colitis
- HER2 negative hormone receptor negative breast cancer
- inflammatory bowel disease
- infection by bacteria
role in cell
- differentiation
- chemotaxis
- function
- chemotaxis by
- response by
- migration by
- acidification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLAMF8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of kinase activity
- negative regulation of respiratory burst involved in inflammatory response
- negative regulation of dendritic cell chemotaxis
- B-1 B cell lineage commitment
- negative regulation of monocyte chemotaxis
- regulation of B cell differentiation
- regulation of NAD(P)H oxidase activity
- phagosome acidification
- negative regulation of macrophage chemotaxis
- leukocyte chemotaxis involved in inflammatory response
- defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- signaling receptor activity