Slamf8 Gene Summary [Mouse]
Enables identical protein binding activity and signaling receptor activity. Involved in B-1 B cell lineage commitment and regulation of B cell differentiation. Acts upstream of or within several processes, including leukocyte chemotaxis involved in inflammatory response; negative regulation of leukocyte migration; and negative regulation of respiratory burst involved in inflammatory response. Predicted to be located in membrane. Orthologous to human SLAMF8 (SLAM family member 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slamf8 |
| Official Name | SLAM family member 8 [Source:MGI Symbol;Acc:MGI:1921998] |
| Ensembl ID | ENSMUSG00000053318 |
| Bio databases IDs | |
| Aliases | SLAM family member 8 |
| Synonyms | 5830408F06Rik, BLAME, CD353, LOC100048553, SBBI42, SLAM family member 8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slamf8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Crohn disease
- nasal type extranodal NK-/T-cell lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- natural killer cell neoplasia
- ulcerative colitis
- HER2 negative hormone receptor negative breast cancer
- inflammatory bowel disease
- infection by bacteria
role in cell
- differentiation
- chemotaxis
- function
- chemotaxis by
- response by
- migration by
- acidification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slamf8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of kinase activity
- negative regulation of respiratory burst involved in inflammatory response
- negative regulation of dendritic cell chemotaxis
- B-1 B cell lineage commitment
- negative regulation of monocyte chemotaxis
- regulation of B cell differentiation
- regulation of NAD(P)H oxidase activity
- phagosome acidification
- negative regulation of macrophage chemotaxis
- leukocyte chemotaxis involved in inflammatory response
- defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- signaling receptor activity