ULBP3 Gene Summary [Human]
The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | ULBP3 |
| Official Name | UL16 binding protein 3 [Source:HGNC Symbol;Acc:HGNC:14895] |
| Ensembl ID | ENSG00000131019 |
| Bio databases IDs | |
| Aliases | UL16 binding protein 3 |
| Synonyms | N2DL3, NKG2DL3, NKG2D ligand 3, RAET1N, UL16 binding protein 3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ULBP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Class I Histocompatibility antigen, domains alpha 1 and 2
- natural killer cell lectin-like receptor binding
- protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the ULBP3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- detergent resistant lipid raft fraction
- cell surface
- immunological synapses
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ULBP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- natural killer cell activation
- positive regulation of T cell mediated cytotoxicity
- natural killer cell mediated cytotoxicity
- antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib
Cellular Component
Where in the cell the gene product is active
- extracellular space
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- natural killer cell lectin-like receptor binding