DONSON Gene Summary [Human]
This gene lies downstream of the SON gene and spans 10 kb on chromosome 21. The function of this gene is unknown. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | DONSON |
| Official Name | DNA replication fork stabilization factor DONSON [Source:HGNC Symbol;Acc:HGNC:2993] |
| Ensembl ID | ENSG00000159147 |
| Bio databases IDs | |
| Aliases | DNA replication fork stabilization factor DONSON |
| Synonyms | 1110025J21Rik, B17, C21orf60, DNA replication fork stabilization factor DONSON, downstream neighbor of SON, MIMIS, MISSLA, ORF60 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DONSON often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- microcephalic primordial dwarfism
- microcephaly
- microcephaly, short stature and limb abnormalities
- hereditary disorder
- Huntington disease
- breast cancer
- Meier-Gorlin syndrome
- small cell lung cancer
- microcephaly-micromelia syndrome
role in cell
- invasion by
- phosphorylation in
- proliferation
- apoptosis
- quantity
- migration
- G2/M phase
- origin firing in
- processing
- S/G2 phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DONSON gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle G2/M transition DNA damage checkpoint
- DNA replication involved in S phase
- DNA damage checkpoint
- DNA replication
- replication fork processing
- mitotic cell cycle DNA replication checkpoint
Cellular Component
Where in the cell the gene product is active
- replication fork
- nucleus
- replisome
Molecular Function
What the gene product does at the molecular level
- protein binding