Donson Gene Summary [Mouse]
Predicted to be involved in DNA-templated DNA replication and mitotic G2/M transition checkpoint. Predicted to be located in replication fork. Predicted to be part of replisome. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb; and sensory organ. Human ortholog(s) of this gene implicated in microcephaly, short stature, and limb abnormalities and microcephaly-micromelia syndrome. Orthologous to human DONSON (DNA replication fork stabilization factor DONSON). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Donson |
| Official Name | downstream neighbor of SON [Source:MGI Symbol;Acc:MGI:1890621] |
| Ensembl ID | ENSMUSG00000022960 |
| Bio databases IDs | |
| Aliases | downstream neighbor of SON |
| Synonyms | 1110025J21Rik, B17, C21orf60, DNA replication fork stabilization factor DONSON, downstream neighbor of SON, MIMIS, MISSLA, ORF60 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Donson often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- microcephalic primordial dwarfism
- microcephaly
- microcephaly, short stature and limb abnormalities
- hereditary disorder
- Huntington disease
- breast cancer
- Meier-Gorlin syndrome
- small cell lung cancer
- microcephaly-micromelia syndrome
role in cell
- invasion by
- phosphorylation in
- proliferation
- apoptosis
- quantity
- migration
- G2/M phase
- origin firing in
- processing
- S/G2 phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Donson gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle G2/M transition DNA damage checkpoint
- DNA replication involved in S phase
- DNA damage checkpoint
- DNA replication
- replication fork processing
- mitotic cell cycle DNA replication checkpoint
Cellular Component
Where in the cell the gene product is active
- replication fork
- nucleus
- replisome
Molecular Function
What the gene product does at the molecular level
- protein binding