GINS1 Gene Summary [Human]
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | GINS1 |
| Official Name | GINS complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:28980] |
| Ensembl ID | ENSG00000101003 |
| Bio databases IDs | |
| Aliases | GINS complex subunit 1 |
| Synonyms | 2810418N01Rik, Gins4, GINS complex subunit 1, IMD55, KIAA0186, mKIAA0186, PSF1, RGD1562246 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GINS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha-helical domain of GINS complex proteins (Sld5, Psf1, Psf2 and Psf3)
- GINS_B
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- immunodeficiency 55
- hepatitis B virus-related hepatocellular carcinoma
- HER2 negative hormone receptor negative breast cancer
- organismal death
- combined immunodeficiency
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- proliferation
- doxorubicin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GINS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner cell mass cell proliferation
- DNA unwinding involved in replication
Cellular Component
Where in the cell the gene product is active
- nucleus
- CMG complex
- cytoplasm
- GINS complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding