TICRR Gene Summary [Human]
Enables chromatin binding activity. Involved in regulation of DNA-dependent DNA replication initiation. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TICRR |
| Official Name | TOPBP1 interacting checkpoint and replication regulator [Source:HGNC Symbol;Acc:HGNC:28704] |
| Ensembl ID | ENSG00000140534 |
| Bio databases IDs | |
| Aliases | TOPBP1 interacting checkpoint and replication regulator, TOPBP1-interacting replication-stimulating protein, SLD3 homolog (S. cerevisiae) |
| Synonyms | 5730590G19Rik, C15orf42, Lrrk1, RGD1308541, SLD3, TOPBP1-interacting checkpoint and replication regulator, Treslin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TICRR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Family of unknown function (DUF5585)
- Treslin N-terminus
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TICRR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle G2/M transition DNA damage checkpoint
- DNA repair
- DNA replication
- regulation of DNA-dependent DNA replication initiation
- mitotic cell cycle DNA replication checkpoint
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chromatin binding