LAD1 Gene Summary [Human]
The protein encoded by this gene may be an anchoring filament that is a component of basement membranes. It may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LAD1 |
| Official Name | ladinin 1 [Source:HGNC Symbol;Acc:HGNC:6472] |
| Ensembl ID | ENSG00000159166 |
| Bio databases IDs | |
| Aliases | ladinin 1 |
| Synonyms | LADA, ladinin, ladinin 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LAD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- breast cancer
- angioimmunoblastic T-cell lymphoma
- lung adenocarcinoma
- lung adenocarcinoma formation
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- uterine serous papillary cancer
- EGFR mutation positive adenocarcinoma of the lung
- EGFR mutation positive non-small cell lung cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- actin cytoskeleton
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LAD1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- basement membrane
- extracellular vesicular exosome
- actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- cadherin binding
- structural molecule activity