USP4 Gene Summary [Human]
The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | USP4 |
| Official Name | ubiquitin specific peptidase 4 [Source:HGNC Symbol;Acc:HGNC:12627] |
| Ensembl ID | ENSG00000114316 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 4 |
| Synonyms | F730026I20Rik, LOC107986084, mKIAA4155, ubiquitin specific peptidase 4, ubiquitin specific peptidase 4 (proto-oncogene), UNP, Unph |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human USP4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin thiolesterase
- catalytic domain
- peptidase
- nuclear localization sequence
- G-protein-coupled receptor binding
- ubiquitin-specific protease
- DUSP domain
- LXCXE binding site
- protein binding
- ubiquitin-like domain
- identical protein binding
Pathways
Biological processes and signaling networks where the USP4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- opioid-related disorder
- neoplasia
- organismal death
- cannabis dependence
- major depression
- dilated cardiomyopathy
- metastasis
- pervasive developmental disorder
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
role in cell
- number
- proliferation
- production in
- binding in
- invasion by
- expression in
- tyrosine phosphorylation in
- activation in
- cell viability
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- lysosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human USP4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- protein localization at cell surface
- regulation of protein stability
- proteolysis
- negative regulation of protein ubiquitination
- assembly of spliceosomal tri-snRNP
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- identical protein binding
- protein binding
- metal ion binding
- adenosine receptor binding