Lad1 Gene Summary [Mouse]
Predicted to enable structural molecule activity. Predicted to be located in actin cytoskeleton. Is expressed in several structures, including ganglia; incisor; sensory organ; submandibular gland primordium; and thymus primordium. Orthologous to human LAD1 (ladinin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lad1 |
| Official Name | ladinin [Source:MGI Symbol;Acc:MGI:109343] |
| Ensembl ID | ENSMUSG00000041782 |
| Bio databases IDs | |
| Aliases | ladinin |
| Synonyms | LADA, ladinin, ladinin 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lad1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- breast cancer
- angioimmunoblastic T-cell lymphoma
- lung adenocarcinoma
- lung adenocarcinoma formation
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- uterine serous papillary cancer
- EGFR mutation positive adenocarcinoma of the lung
- EGFR mutation positive non-small cell lung cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- actin cytoskeleton
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lad1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- basement membrane
- extracellular vesicular exosome
- actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- cadherin binding
- structural molecule activity