WDR26 Gene Summary [Human]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
WDR26
Official Name
WD repeat domain 26 [Source:HGNC Symbol;Acc:HGNC:21208]
Ensembl ID
ENSG00000162923
Bio databases IDs NCBI: 80232 Ensembl: ENSG00000162923
Aliases WD repeat domain 26, GID complex subunit 7 homolog (S. cerevisiae)
Synonyms 1600024A01Rik, AU044014, CDW2, GID7, LOC114227, MIP2, RGD1565589, SKDEAS, WD repeat domain 26
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WDR26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • WD-like repeat
  • LisH-like dimerization domain
  • WD40 repeats
  • WD domain, G-beta repeat
  • C-terminal to LisH motif
  • WD40
  • LisH-CTLH domain
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • hereditary disorder
  • Skraban-Deardorff syndrome
  • idiopathic scoliosis
  • mental retardation
regulated by
  • AGT
  • AGTR1
  • NR3C1
  • hydrogen peroxide
  • budesonide
  • Jurkat cells
  • gabapentin
regulates
  • PI3K (complex)
  • G protein beta gamma core
  • PLCB2
  • RACK1
  • cytochrome C
role in cell
  • chemotaxis
  • migration
  • activation in
  • apoptosis
  • signaling in
  • binding in
  • homing

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Nucleus
  • Mitochondria
  • cytosol
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human WDR26 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • proteasomal ubiquitin-dependent protein catabolic process

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • ubiquitin ligase complex
  • cytoplasm
  • mitochondrion
  • cytosol
  • GID complex
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.