CBR1 Gene Summary [Human]
The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
Details
| Type | Processed Transcript |
| Official Symbol | CBR1 |
| Official Name | carbonyl reductase 1 [Source:HGNC Symbol;Acc:HGNC:1548] |
| Ensembl ID | ENSG00000159228 |
| Bio databases IDs | |
| Aliases | carbonyl reductase 1, short chain dehydrogenase/reductase family 21C, member 1 |
| Synonyms | Carbonyl Reductase, carbonyl reductase 1, CBR, CR, CRN, hCBR1, LOC100912203, Ocr, PG-9-KR, SDR21C1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CBR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- 15-hydroxyprostaglandin dehydrogenase (NADP)
- prostaglandin-E2 9-reductase
- CH-OH group:NAD or NADP oxidoreductase
- enzyme
- protein binding
- Enoyl-(Acyl carrier protein) reductase
- short chain dehydrogenase
- carbonyl reductase (NADPH)
- NADH or NADPH:quinone oxidoreductase
Pathways
Biological processes and signaling networks where the CBR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiotoxicity
- Down syndrome
- metastasis
- aortic valve calcification
- chronic sinusitis
- atopic dermatitis
role in cell
- proliferation
- production in
- cell death
- survival
- generation in
- fasciculation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CBR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- cyclooxygenase pathway
- vitamin K metabolic process
- xenobiotic metabolic process
- glucocorticoid metabolic process
- positive regulation of reactive oxygen species metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- carbonyl reductase (NADPH) activity
- prostaglandin-E2 9-reductase activity
- 15-hydroxyprostaglandin dehydrogenase (NADP+) activity
- 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- alcohol dehydrogenase (NADP+) activity
- oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor