PLA2G4D Gene Summary [Human]
The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids (Chiba et al., 2004 [PubMed 14709560]).[supplied by OMIM, Jun 2009]
Details
| Type | Retained Intron |
| Official Symbol | PLA2G4D |
| Official Name | phospholipase A2 group IVD [Source:HGNC Symbol;Acc:HGNC:30038] |
| Ensembl ID | ENSG00000159337 |
| Bio databases IDs | |
| Aliases | phospholipase A2 group IVD |
| Synonyms | 2610311B01RIK, cPLA2delta, phospholipase A2 group IVD, phospholipase A2, group IVD, Pla2delta, RGD1305282 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLA2G4D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Patatins and Phospholipases
- Cytoplasmic phospholipase A2, catalytic subunit
- phospholipase A1
- Cytosolic phospholipases A2 C2-domain
- calcium-dependent phospholipase A2
- enzyme
- Protein kinase C conserved region 2 (CalB)
- phospholipase A2
- C2 domain
Pathways
Biological processes and signaling networks where the PLA2G4D gene in human plays a role, providing insight into its function and relevance in health or disease.
- Antioxidant Action of Vitamin C
- Atherosclerosis Signaling
- CCR3 Signaling in Eosinophils
- Docosahexaenoic Acid (DHA) Signaling
- Eicosanoid Signaling
- Endothelin-1 Signaling
- ERK/MAPK Signaling
- Fc Epsilon RI Signaling
- Glucocorticoid Receptor Signaling
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- Neuroinflammation Signaling Pathway
- p38 MAPK Signaling
- Phagosome Formation
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Serotonin Receptor Signaling
- Sperm Motility
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pruritus
role in cell
- expression in
- accumulation in
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLA2G4D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerophospholipid catabolic process
- phosphatidylglycerol acyl-chain remodeling
- phosphatidylinositol acyl-chain remodeling
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- calcium-dependent phospholipase A2 activity
- calcium ion binding
- phosphatidylcholine 1-acylhydrolase activity
- calcium-dependent phospholipid binding