IL23A Gene Summary [Human]
This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | IL23A |
| Official Name | interleukin 23 subunit alpha [Source:HGNC Symbol;Acc:HGNC:15488] |
| Ensembl ID | ENSG00000110944 |
| Bio databases IDs | |
| Aliases | interleukin 23 subunit alpha, interleukin-six, G-CSF related factor |
| Synonyms | IL-23, IL23P19, interleukin 23, alpha subunit p19, interleukin 23 p19 subunit, interleukin 23 subunit alpha, interleukin 23 subunit α, interleukin 23, α subunit p19, P19, SGRF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL23A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Interleukin-6/G-CSF/MGF family
- interleukin-23 receptor binding
- protein binding
- cytokine
- Interleukin 23 subunit alpha
Pathways
Biological processes and signaling networks where the IL23A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- neoplasia
- ulcerative colitis
- Crohn disease
- pruritus
- psoriasis
- insulin-dependent diabetes mellitus
- cardiovascular disorder
- fistulizing Crohn disease
- hyperplasia
role in cell
- activation in
- expression in
- activation
- proliferation
- quantity
- phosphorylation in
- activity
- growth
- formation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- endoplasmic reticulum lumen
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL23A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-10 production
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of T-helper 17 type immune response
- inflammatory response
- positive regulation of granulocyte macrophage colony-stimulating factor production
- positive regulation of osteoclast differentiation
- positive regulation of interferon-gamma production
- positive regulation of NK T cell proliferation
- positive regulation of interleukin-17 production
- positive regulation of tissue remodeling
- defense response to virus
- positive regulation of activation of Janus kinase activity
- positive regulation of tumor necrosis factor production
- positive regulation of T-helper 17 cell lineage commitment
- defense response to Gram-negative bacterium
- signal transduction
- positive regulation of neutrophil chemotaxis
- regulation of tyrosine phosphorylation of STAT protein
- positive regulation of inflammatory response
- positive regulation of T cell proliferation
- positive regulation of defense response to virus by host
- positive regulation of activated T cell proliferation
- tissue remodeling
- positive regulation of interleukin-12 production
- positive regulation of NK T cell activation
- positive regulation of natural killer cell proliferation
- positive regulation of memory T cell differentiation
- innate immune response
- positive regulation of natural killer cell activation
- T cell proliferation
- positive regulation of T-helper 1 type immune response
- positive regulation of T cell mediated cytotoxicity
- positive regulation of interleukin-10 production
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- interleukin-23 complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- interleukin-23 receptor binding
- protein binding
- cytokine activity