GET4 Gene Summary [Human]
Enables chaperone binding activity. Involved in cytoplasmic sequestering of protein; maintenance of unfolded protein involved in ERAD pathway; and tail-anchored membrane protein insertion into ER membrane. Located in chromosome; cytosol; and nuclear lumen. Part of BAT3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GET4 |
| Official Name | guided entry of tail-anchored proteins factor 4 [Source:HGNC Symbol;Acc:HGNC:21690] |
| Ensembl ID | ENSG00000239857 |
| Bio databases IDs | |
| Aliases | guided entry of tail-anchored proteins factor 4, CGI-20 protein, conserved edge protein, transmembrane domain recognition complex, 35kDa |
| Synonyms | 1110007L15Rik, C7orf20, CDG2Y, CEE, CGI-20, golgi to ER traffic protein 4, guided entry of tail-anchored proteins factor 4, LOC51608, RGD1311660, TRC35 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GET4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Golgi to ER traffic protein 4
- protein binding
- chaperone binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GET4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein stability
- tail-anchored membrane protein insertion into ER membrane
- cytoplasmic sequestering of protein
- protein insertion into ER membrane
- posttranslational protein targeting to membrane
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- BAT3 complex
- cytoplasm
- cytosol
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chaperone binding