FCN2 Gene Summary [Human]
The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FCN2 |
| Official Name | ficolin 2 [Source:HGNC Symbol;Acc:HGNC:3624] |
| Ensembl ID | ENSG00000160339 |
| Bio databases IDs | |
| Aliases | ficolin 2, hucolin, collagen/fibrinogen domain-containing protein 2, ficolin B, serum lectin p35, L-ficolin |
| Synonyms | EBP-37, FCNL, ficolin-2, hucolin, L-FICOLIN, P35 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FCN2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- collagen-like domain
- Fibrinogen-like terminal knob
- binding protein
- fibrinogen-like domain
- antigen binding
- protein binding
- polysaccharide binding
- identical protein binding
- FReD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- severe COVID-19
- diabetic nephropathy
- COVID-19
- osteoporosis
- hepatocellular carcinoma
- hepatitis B virus-related hepatocellular carcinoma
- infection by Hepatitis C virus genotype 2
- infection by Zaire ebolavirus
role in cell
- expression in
- binding in
- entrance
- attachment
- attachment in
- viral entry
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FCN2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell surface pattern recognition receptor signaling pathway
- defense response to Gram-negative bacterium
- complement activation, lectin pathway
- proteolysis
- recognition of apoptotic cell
- opsonization
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- collagen
- blood microparticle
- external side of plasma membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- mannan binding
- protein binding
- proteoglycan binding
- antigen binding
- metal ion binding
- calcium-dependent protein binding
- receptor binding