SCARB1 Gene Summary [Human]
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2 and facilitates cell entry by the virus, SARS-CoV2. [provided by RefSeq, Oct 2021]
Details
| Type | Protein Coding |
| Official Symbol | SCARB1 |
| Official Name | scavenger receptor class B member 1 [Source:HGNC Symbol;Acc:HGNC:1664] |
| Ensembl ID | ENSG00000073060 |
| Bio databases IDs | |
| Aliases | scavenger receptor class B member 1 |
| Synonyms | CD36, CD36L1, Chohd1, CLA-1, D5Ertd460e, HDLCQ6, Hdlq1, HDLQTL6, HDL Receptor, Hlb398, mSR-BI, SCAVENGER receptor B1, Scavenger receptor class b1, scavenger receptor class B member 1, scavenger receptor class B, member 1, SR-B, SR-B1, SR-BI |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SCARB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- phospholipid binding
- signaling receptor activity
- lipoprotein receptor
- high-density lipoprotein binding
- beta-amyloid binding
- low-density lipoprotein binding
- protein binding
- identical protein binding
- lipopolysaccharide binding
- phosphatidylinositol binding
- lipid transporter
- binding protein
- N-linked glycosylation site
- scavenger receptor
- cytoplasmic domain
- transmembrane domain
- hypervariable region
- glycosylation site
- CD36 family
- transporter
Pathways
Biological processes and signaling networks where the SCARB1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sepsis
- neoplasia
- epithelial cancer
- adenoma formation
- prostate cancer
- hyperlipidemia
- coronary artery disease
- cholelithiasis
- myocardial infarction
- Waldenström macroglobulinemia
role in cell
- expression in
- apoptosis
- cell death
- migration
- production in
- proliferation
- formation
- quantity
- uptake in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- raft fractions
- membrane fraction
- endocytic vesicle membrane
- intracellular membrane-bounded organelle
- cholesterol-rich microdomain
- Cytoplasm
- cell surface
- cell borders
- intracellular space
- perinuclear region
- cellular membrane
- vesicles
- lysosome
- apical cell surfaces
- caveolar membranes
- apical membrane
- caveolae
- basolateral membrane
- basal membrane
- sinusoidal membrane
- perinuclear space
- multivesicular bodies
- membrane rafts
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SCARB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- cholesterol import
- high-density lipoprotein particle remodeling
- vitamin transmembrane transport
- cholesterol homeostasis
- wound healing
- positive regulation of nitric-oxide synthase activity
- reverse cholesterol transport
- regulation of phosphatidylcholine catabolic process
- triglyceride homeostasis
- positive regulation of endothelial cell migration
- lipopolysaccharide transport
- low-density lipoprotein particle clearance
- adhesion to host
- plasma lipoprotein particle clearance
- high-density lipoprotein particle clearance
- blood vessel endothelial cell migration
- recognition of apoptotic cell
- carotenoid transport
- cholesterol catabolic process
- positive regulation of triglyceride biosynthetic process
- positive regulation of cholesterol storage
- endothelial cell proliferation
- lipopolysaccharide-mediated signaling pathway
- phospholipid transport
- cholesterol efflux
- detection of lipopolysaccharide
- regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- caveola
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- plasma membrane
- lysosomal membrane
- endocytic vesicle membrane
- cell surface
- lysosome
Molecular Function
What the gene product does at the molecular level
- apolipoprotein binding
- high-density lipoprotein particle receptor activity
- apolipoprotein A-I binding
- scavenger receptor activity
- lipid binding
- high-density lipoprotein particle binding
- beta-amyloid binding
- 1-phosphatidylinositol binding
- lipopolysaccharide binding
- phosphatidylserine binding
- protein binding
- lipopolysaccharide receptor activity
- viral receptor activity
- low-density lipoprotein particle binding