Flad1 Gene Summary [Rat]
Predicted to enable FMN adenylyltransferase activity and identical protein binding activity. Predicted to be involved in FAD biosynthetic process and riboflavin metabolic process. Predicted to be located in mitochondrion and plasma membrane. Predicted to be active in cytosol and mitochondrial matrix. Orthologous to human FLAD1 (flavin adenine dinucleotide synthetase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Flad1 |
| Official Name | flavin adenine dinucleotide synthetase 1 [Source:RGD Symbol;Acc:1593292] |
| Ensembl ID | ENSRNOG00000020642 |
| Bio databases IDs | |
| Aliases | flavin adenine dinucleotide synthetase 1 |
| Synonyms | A930017E24Rik, FAD1, FADS, flavin adenine dinucleotide synthetase 1, LSMFLAD, PP591 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Flad1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Probable molybdopterin binding domain
- enzyme
- protein binding
- MoCF_BD
- identical protein binding
- Adenine nucleotide alpha hydrolase (AANH) superfamily
- FMN adenylyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lipid storage myopathy due to flavin adenine dinucleotide synthetase deficiency
- myopathy with abnormal lipid metabolism
- glutaric aciduria type 2
- senile lentigo
regulates
- riboflavin
- adenine-riboflavin dinucleotide
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Flad1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- FAD biosynthetic process
- riboflavin metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- FMN adenylyltransferase activity