MGAT4B Gene Summary [Human]
This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MGAT4B |
| Official Name | alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B [Source:HGNC Symbol;Acc:HGNC:7048] |
| Ensembl ID | ENSG00000161013 |
| Bio databases IDs | |
| Aliases | alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B |
| Synonyms | alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B, GNT-IV, GNT-IVB, mannoside acetylglucosaminyltransferase 4, isoenzyme B, RGD1562836, α-1,3-mannosyl-glycoprotein 4-β-N-acetylglucosaminyltransferase B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MGAT4B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acetylglucosaminyltransferase
- enzyme
- protein binding
- alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
- glycosyltransferase
- Post-GPI attachment to proteins factor 4 and similar proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MGAT4B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral protein processing
- N-glycan processing
- protein glycosylation
- protein N-linked glycosylation
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment
- Golgi stack
Molecular Function
What the gene product does at the molecular level
- protein binding
- acetylglucosaminyltransferase activity
- metal ion binding
- alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity