SENP3
SENP3 Gene Summary
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
Details
| Type | Protein Coding |
| Official Symbol | SENP3 |
| Official Name | SUMO specific peptidase 3 [Source:HGNC Symbol;Acc:HGNC:17862] |
| Ensembl ID | ENSG00000161956 |
| Bio databases IDs | |
| Aliases | SUMO specific peptidase 3 |
| Synonyms | Smt3ip,SMT3IP1,SSP3,SUMO/sentrin specific peptidase 3,SUMO specific peptidase 3,SUSP3,Ulp1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SUMO-specific protease
- cysteine-type peptidase
- Ulp1 protease family, C-terminal catalytic domain
- peptidase
- ubiquitin-specific protease
- protein binding
Pathways
Biological processes and signaling networks where the SENP3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- WDR18
- HSP90 (family)
- DDX27
- TRIM28
- NR3C1
- GANAB
- ESF1
- TCF7L2
- CHTOP
- TCTN3
disease
- metastasis
- neoplasia
- hepatocellular carcinoma
- epithelial cancer
- colon epithelial cancer
- bladder cancer
- tumorigenesis
- metabolic syndrome X
- Alzheimer disease
- liver cancer
regulated by
- hydrogen peroxide
- CDK6
- HSP90 (family)
- CC2D1A
- STUB1
- N-acetyl-L-cysteine
- PRKAR1A
- IGF2BP1
- CDKN2A
- reactive oxygen species
regulates
- IL1B
- IL12B
- HLA-A
- Ccl3
- Ccl4
- STING1
- IL12A
- MDM2
- SUMO2
- RANGAP1
role in cell
- proliferation
- expression in
- phosphorylation in
- processing in
- molecular cleavage in
- degradation in
- invasion by
- number
- migratory capacity
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- nucleoplasm
- nucleoli
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SENP3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of double-strand break repair via homologous recombination
- protein desumoylation
- proteolysis
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleolus
- nucleoplasm
- MLL1 complex
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- SUMO-specific protease activity
- cysteine-type peptidase activity