NOL9 Gene Summary [Human]
Enables polynucleotide 5'-hydroxyl-kinase activity. Involved in maturation of 5.8S rRNA. Located in intermediate filament cytoskeleton and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NOL9 |
| Official Name | nucleolar protein 9 [Source:HGNC Symbol;Acc:HGNC:26265] |
| Ensembl ID | ENSG00000162408 |
| Bio databases IDs | |
| Aliases | nucleolar protein 9, polynucleotide 5'-kinase |
| Synonyms | 4632412I24RIK, 6030462G04Rik, AI449622, AW490720, Grc3, NET6, nucleolar protein 9 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NOL9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Pre-mRNA cleavage complex II protein Clp1
- ATP binding
- protein binding
- polynucleotide 5'-hydroxyl-kinase
- P-loop containing Nucleoside Triphosphate Hydrolases
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intermediate filament cytoskeleton
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NOL9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of 5.8S rRNA
- cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular Component
Where in the cell the gene product is active
- nucleus
- intermediate filament cytoskeleton
- membrane
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- polynucleotide 5'-hydroxyl-kinase activity
- protein binding
- RNA binding
- ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
- ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity