FBLIM1 Gene Summary [Human]
This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FBLIM1 |
| Official Name | filamin binding LIM protein 1 [Source:HGNC Symbol;Acc:HGNC:24686] |
| Ensembl ID | ENSG00000162458 |
| Bio databases IDs | |
| Aliases | filamin binding LIM protein 1 |
| Synonyms | 2410043F08Rik, CAL, DKFZp434G171, FBLI1, FBLP-1, filamin binding LIM protein 1, Gt10, hnRNP L, MIGFILIN, migfilin(s) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBLIM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- filamin binding domain
- cytoskeletal protein binding
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- double-stranded DNA binding
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- polyproline motif
- proline rich domain
- RNA binding
Pathways
Biological processes and signaling networks where the FBLIM1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- androgenic alopecia
- glioma
- glioma formation
- laser induced choroidal neovascularization
- alcoholic pancreatitis
- infection by HIV-1
role in cell
- expression in
- binding in
- activation in
- proliferation
- phosphorylation in
- accumulation in
- differentiation
- migration
- apoptosis
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- fibrillar center
- cell junction
- ribonucleoprotein granule
- Cytoplasm
- cell-matrix contacts
- cell periphery
- focal adhesions
- Nucleus
- actin bundles
- intercellular junctions
- cell-cell contacts
- cytosol
- nucleoplasm
- actin stress fibers
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBLIM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- regulation of integrin activation
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytoplasm
- stress fiber
- cytosol
- cell junction
- fibrillar center
- cell periphery
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- filamin binding