IL23R Gene Summary [Human]
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL23R |
| Official Name | interleukin 23 receptor [Source:HGNC Symbol;Acc:HGNC:19100] |
| Ensembl ID | ENSG00000162594 |
| Bio databases IDs | |
| Aliases | interleukin 23 receptor |
| Synonyms | IL-23R-alpha, IL-23 receptor, IL-23R-α, interleukin 23 receptor, LOC100364993, LOC100912239, LOC103690079, LOC683816, PSORS7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL23R often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytokine binding module
- extracellular domain
- FNIII-like repeat
- FN3
- interleukin-12 receptor binding
- immunoglobulin-like protein domain
- interleukin-23 receptor
- Fibronectin type 3 domain
- protein binding
- cytokine receptor
- interleukin-23 binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the IL23R gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- precursor B-cell acute lymphoblastic leukemia
- neoplasia
- experimental autoimmune encephalomyelitis
- Crohn disease
- autoimmune disease
- psoriasis
- inflammatory bowel disease
- ulcerative colitis
- rheumatoid arthritis
role in cell
- expression in
- growth
- proliferation
- number
- quantity
- phosphorylation in
- apoptosis
- production in
- infiltration by
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL23R gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-10 production
- interleukin-23-mediated signaling pathway
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of T-helper 17 type immune response
- inflammatory response
- positive regulation of granulocyte macrophage colony-stimulating factor production
- positive regulation of osteoclast differentiation
- cytokine-mediated signaling pathway
- positive regulation of interferon-gamma production
- positive regulation of interleukin-17 production
- positive regulation of activation of Janus kinase activity
- positive regulation of T-helper 17 cell lineage commitment
- defense response to Gram-negative bacterium
- response to interferon-gamma
- regulation of tyrosine phosphorylation of STAT protein
- positive regulation of T cell proliferation
- positive regulation of defense response to virus by host
- positive regulation of activated T cell proliferation
- positive regulation of interleukin-12 production
- positive regulation of NK T cell activation
- positive regulation of memory T cell differentiation
- positive regulation of natural killer cell proliferation
- positive regulation of T-helper 1 type immune response
- response to lipopolysaccharide
- positive regulation of T cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- interleukin-23 receptor complex
- external side of plasma membrane
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- interleukin-23 binding
- protein binding
- interleukin-23 receptor activity
- interleukin-12 receptor binding
- cytokine binding
- cytokine receptor activity