GBP4 Gene Summary [Human]
Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008]
Details
| Type | Protein Coding |
| Official Symbol | GBP4 |
| Official Name | guanylate binding protein 4 [Source:HGNC Symbol;Acc:HGNC:20480] |
| Ensembl ID | ENSG00000162654 |
| Bio databases IDs | |
| Aliases | guanylate binding protein 4 |
| Synonyms | guanylate binding protein 4, Mpa2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GBP4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Guanylate-binding protein, N-terminal domain
- protein homodimerization
- protein binding
- identical protein binding
- Guanylate-binding protein, C-terminal domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- perinuclear region
- Plasma Membrane
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GBP4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to interferon-gamma
- defense response to Gram-positive bacterium
- defense response to protozoan
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytosol
- cytoplasmic vesicle
- Golgi apparatus
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- identical protein binding
- protein binding
- protein homodimerization activity
- GTPase activity