GBP5 Gene Summary [Human]
This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]
Details
| Type | Retained Intron |
| Official Symbol | GBP5 |
| Official Name | guanylate binding protein 5 [Source:HGNC Symbol;Acc:HGNC:19895] |
| Ensembl ID | ENSG00000154451 |
| Bio databases IDs | |
| Aliases | guanylate binding protein 5 |
| Synonyms | guanylate binding protein 5 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GBP5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase inhibitor
- Guanylate-binding protein, N-terminal domain
- protein homodimerization
- GTPase
- enzyme
- protein binding
- identical protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- Guanylate-binding protein, C-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- early missed abortion
- hepatitis B virus-related hepatocellular carcinoma
- diabetes mellitus
- tuberculosis
- hepatitis
- diabetic retinopathy
- renal clear cell adenocarcinoma
role in cell
- apoptosis
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- Golgi Apparatus
- cytosol
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GBP5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization in Golgi apparatus
- positive regulation of NLRP3 inflammasome complex assembly
- defense response to bacterium
- positive regulation of cytokine production involved in inflammatory response
- protein targeting
- inflammatory response
- protein homotetramerization
- positive regulation of innate immune response
- cellular response to lipopolysaccharide
- activation of innate immune response
- defense response to virus
- positive regulation of interleukin-18 production
- cellular response to interferon-gamma
- cytolysis in other organism
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- cytoplasmic vesicle
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- GTP binding
- identical protein binding
- protein binding
- endopeptidase inhibitor activity
- protein homodimerization activity
- GTPase activity