GBP2 Gene Summary [Human]
This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | GBP2 |
| Official Name | guanylate binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4183] |
| Ensembl ID | ENSG00000162645 |
| Bio databases IDs | |
| Aliases | guanylate binding protein 2 |
| Synonyms | guanylate binding protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GBP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- endopeptidase inhibitor
- GTP binding domain
- Ezrin/radixin/moesin, alpha-helical domain
- Guanylate-binding protein, N-terminal domain
- ClassIIa_HDAC_Gln-rich-N
- protein homodimerization
- protein binding
- identical protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- Guanylate-binding protein, C-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- ulcerative colitis
- rheumatoid arthritis
- hepatocellular carcinoma
- liver cancer
- psoriasis
- Alzheimer disease
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- expression in
- migration
- invasion by
- growth
- induction in
- invasiveness
- response by
- contact growth inhibition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Plasma Membrane
- vesicles
- Golgi Apparatus
- cytosol
- Golgi membrane
- nucleoplasm
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GBP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to bacterium
- defense response to protozoan
- immune response
- cellular response to lipopolysaccharide
- activation of innate immune response
- cellular response to interleukin-1
- defense response to virus
- cellular response to tumor necrosis factor
- cytolysis in other organism
- cellular response to interferon-gamma
- protein localization to nucleus
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic vesicle membrane
- perinuclear region of cytoplasm
- cytoplasm
- cytoplasmic vesicle
- cytosol
- Golgi membrane
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- identical protein binding
- protein binding
- protein homodimerization activity
- endopeptidase inhibitor activity
- GTPase activity