RBM15 Gene Summary [Human]
Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]
Details
| Type | Protein Coding |
| Official Symbol | RBM15 |
| Official Name | RNA binding motif protein 15 [Source:HGNC Symbol;Acc:HGNC:14959] |
| Ensembl ID | ENSG00000162775 |
| Bio databases IDs | |
| Aliases | RNA binding motif protein 15, one twenty-two |
| Synonyms | C230088J01RIK, mKIAA1438, OTT, OTT1, RNA binding motif protein 15, SPEN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RBM15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPOC (Spen paralog and ortholog C-terminal) domain superfamily
- RNA recognition motif (RRM) superfamily
- Spen paralog and ortholog C-terminal domain
- RNA recognition motif
- mRNA binding
- SPOC domain
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- melanoma cancer
- cervical cancer
- colorectal cancer
- pancreatic cancer
- soft tissue sarcoma cancer
- pulmonary hypertensive arterial disease
- organismal death
- glioblastoma
- glioblastoma cancer
- neuroblastoma
role in cell
- proliferation
- quantity
- differentiation
- G2/M phase
- expansion
- alternative splicing by
- splicing in
- signaling in
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spliceosomes
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RBM15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of myeloid cell differentiation
- placenta blood vessel development
- spleen development
- positive regulation of transcription of Notch receptor target
- regulation of megakaryocyte differentiation
- dosage compensation by inactivation of X chromosome
- thrombopoietin-mediated signaling pathway
- ventricular septum morphogenesis
- RNA methylation
- negative regulation of transcription, DNA-dependent
- patterning of blood vessels
- regulation of alternative nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- nuclear speck
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding