EGR1 Gene Summary [Human]
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]
Details
| Type | Protein Coding |
| Official Symbol | EGR1 |
| Official Name | early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] |
| Ensembl ID | ENSG00000120738 |
| Bio databases IDs | |
| Aliases | early growth response 1, nerve growth factor-induced protein A, transcription factor ETR103, zinc finger gene 225, early growth response protein 1 |
| Synonyms | A530045N19Rik, AT225, Early Growth Response 1, egr, ETR103, G0S30, Krox-1, KROX-24, Ngf1, NGF1-A, Ngfi, NGFI-A, TIS8, V5, Zenk, Zfp-6, ZIF-268, ZIF/268, ZNF225 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EGR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc finger DNA binding domain
- transcription regulator
- chromatin binding
- Domain of unknown function (DUF3432)
- C2H2-type zinc finger
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc ion binding
- Zinc-finger double domain
- corepressor binding domain
- histone acetyltransferase binding
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- DNA binding domain
- nucleic acid binding
- r1 domain
- enzyme binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- Early growth response N-terminal domain
- zinc finger
- transcription repression domain
- double-stranded DNA binding
- zinc finger domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the EGR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- anemia
- multiple sclerosis
- benign neoplasia
- adenoma formation
- epithelial neoplasia
- epithelial cancer
- liver cancer
- neoplasia
- diabetes mellitus
role in cell
- binding in
- quantity
- contact growth inhibition
- expression in
- apoptosis
- phosphorylation in
- invasion by
- activation in
- function
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cell surface
- nucleoplasm
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EGR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of progesterone biosynthetic process
- circadian temperature homeostasis
- regulation of neuron apoptotic process
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- response to glucose stimulus
- circadian regulation of gene expression
- response to hypoxia
- response to ischemia
- response to insulin stimulus
- skeletal muscle cell differentiation
- locomotor rhythm
- positive regulation of transcription, DNA-dependent
- BMP signaling pathway
- positive regulation of glomerular metanephric mesangial cell proliferation
- regulation of protein sumoylation
- positive regulation of chemokine production
- positive regulation of hormone biosynthetic process
- hypomethylation of CpG island
- regulation of transcription from RNA polymerase II promoter
- negative regulation of canonical Wnt receptor signaling pathway
- T cell differentiation
- glomerular mesangial cell proliferation
- cellular response to gamma radiation
- positive regulation of gene expression
- interleukin-1-mediated signaling pathway
- cellular response to mycophenolic acid
- positive regulation of interleukin-1 beta production
- cellular response to heparin
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone acetyltransferase binding
- double-stranded methylated DNA binding
- zinc ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding