DENND2D Gene Summary [Human]
Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DENND2D |
| Official Name | DENN domain containing 2D [Source:HGNC Symbol;Acc:HGNC:26192] |
| Ensembl ID | ENSG00000162777 |
| Bio databases IDs | |
| Aliases | DENN domain containing 2D |
| Synonyms | 2010308M01Rik, DENN domain containing 2D, FLJ22457, RGD1305120 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DENND2D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DENN (AEX-3) domain
- guanyl-nucleotide exchange factor
- dDENN domain
- protein binding
- uDENN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DENND2D gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity