Dennd2d Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and respiratory system. Orthologous to human DENND2D (DENN domain containing 2D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Dennd2d |
| Official Name | DENN/MADD domain containing 2D [Source:MGI Symbol;Acc:MGI:2181193] |
| Ensembl ID | ENSMUSG00000027901 |
| Bio databases IDs | |
| Aliases | DENN/MADD domain containing 2D |
| Synonyms | 2010308M01Rik, DENN domain containing 2D, FLJ22457, RGD1305120 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dennd2d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DENN (AEX-3) domain
- guanyl-nucleotide exchange factor
- dDENN domain
- protein binding
- uDENN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dennd2d gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity