PPP2R2C Gene Summary [Human]

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
PPP2R2C
Official Name
protein phosphatase 2 regulatory subunit Bgamma [Source:HGNC Symbol;Acc:HGNC:9306]
Ensembl ID
ENSG00000074211
Bio databases IDs NCBI: 5522 Ensembl: ENSG00000074211
Aliases protein phosphatase 2 regulatory subunit Bgamma, PP2A subunit B isoform gamma
Synonyms 6330548O06RIK, B55-GAMMA, B55-γ, IMYPNO, IMYPNO1, LOC103693768, PP2A-Bgamma, PR52, PR55G, protein phosphatase 2 regulatory subunit Bgamma, protein phosphatase 2, regulatory subunit B, gamma, protein phosphatase 2, regulatory subunit B, γ
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP2R2C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • phosphoprotein phosphatase
  • phosphatase
  • WD40
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • COVID-19
  • acute myeloid leukemia
  • non-insulin-dependent diabetes mellitus
  • insomnia
  • colorectal cancer
  • diabetic nephropathy
  • peripheral arterial disease
  • metastatic prostate cancer
  • idiopathic scoliosis
  • scarlet fever
regulated by
regulates
role in cell
  • migration
  • expression in
  • proliferation
  • phosphorylation in
  • upregulation in
  • outgrowth
  • binding in
  • growth
  • dephosphorylation in
  • neuritogenesis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human PPP2R2C gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • cytosol
  • protein phosphatase type 2A complex

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • protein phosphatase regulator activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.