FCMR Gene Summary [Human]
Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | FCMR |
| Official Name | Fc fragment of IgM receptor [Source:HGNC Symbol;Acc:HGNC:14315] |
| Ensembl ID | ENSG00000162894 |
| Bio databases IDs | |
| Aliases | Fc fragment of IgM receptor, Fc mu receptor, IgM Fc receptor, Fc mu R |
| Synonyms | 1810037B05Rik, FAIM3, FAIM3g, Fc fragment of IgM receptor, FcmuR, Fc mu receptor, IgM FcR, TOSO |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FCMR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fc receptor
- Family of unknown function (DUF5434)
- YXX-Phi motif
- immunoglobulin domain
- transmembrane domain
- Immunoglobulin like
- signal peptide
- intracellular domain
- protein binding
- immunoglobulin binding
- transmembrane receptor
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sepsis
- chronic lymphocytic leukemia
- diabetic nephropathy
- septic shock
- insulin-dependent diabetes mellitus
- chronic form of lymphocytic leukemia
- endometrioma
- acute myeloid leukemia
- infection by bacteria
role in cell
- expression in
- production in
- quantity
- phagocytosis by
- phosphorylation in
- apoptosis
- survival
- phagocytosis
- number
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- centrosome
- Golgi Apparatus
- plasma membrane extracellular face
- trans Golgi network
- lysosome membrane
- endosomal membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FCMR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- humoral immune response mediated by circulating immunoglobulin
- cellular defense response
- immunoglobulin transcytosis in epithelial cells
- negative regulation of apoptotic process
- regulation of B cell receptor signaling pathway
- Fc receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- extracellular region
- trans-Golgi network membrane
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane signaling receptor activity
- high affinity IgM receptor activity
- polymeric immunoglobulin binding
- IgM binding