Fcmr Gene Summary [Mouse]
Enables IgM binding activity. Involved in humoral immune response mediated by circulating immunoglobulin; immunoglobulin transcytosis in epithelial cells; and regulation of B cell receptor signaling pathway. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway and negative regulation of lymphocyte apoptotic process. Located in external side of plasma membrane and trans-Golgi network membrane. Orthologous to human FCMR (Fc mu receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fcmr |
| Official Name | Fc fragment of IgM receptor [Source:MGI Symbol;Acc:MGI:1916419] |
| Ensembl ID | ENSMUSG00000042474 |
| Bio databases IDs | |
| Aliases | Fc fragment of IgM receptor |
| Synonyms | 1810037B05Rik, FAIM3, FAIM3g, Fc fragment of IgM receptor, FcmuR, Fc mu receptor, IgM FcR, TOSO |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fcmr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fc receptor
- Family of unknown function (DUF5434)
- YXX-Phi motif
- immunoglobulin domain
- transmembrane domain
- Immunoglobulin like
- signal peptide
- intracellular domain
- protein binding
- immunoglobulin binding
- transmembrane receptor
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sepsis
- chronic lymphocytic leukemia
- diabetic nephropathy
- septic shock
- insulin-dependent diabetes mellitus
- chronic form of lymphocytic leukemia
- endometrioma
- acute myeloid leukemia
- infection by bacteria
role in cell
- expression in
- production in
- quantity
- phagocytosis by
- phosphorylation in
- apoptosis
- survival
- phagocytosis
- number
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- centrosome
- Golgi Apparatus
- plasma membrane extracellular face
- trans Golgi network
- lysosome membrane
- endosomal membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fcmr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- humoral immune response mediated by circulating immunoglobulin
- cellular defense response
- immunoglobulin transcytosis in epithelial cells
- negative regulation of apoptotic process
- regulation of B cell receptor signaling pathway
- Fc receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- extracellular region
- trans-Golgi network membrane
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane signaling receptor activity
- high affinity IgM receptor activity
- polymeric immunoglobulin binding
- IgM binding