VPS72 Gene Summary [Human]
The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Details
| Type | Protein Coding |
| Official Symbol | VPS72 |
| Official Name | vacuolar protein sorting 72 homolog [Source:HGNC Symbol;Acc:HGNC:11644] |
| Ensembl ID | ENSG00000163159 |
| Bio databases IDs | |
| Aliases | vacuolar protein sorting 72 homolog |
| Synonyms | CFL1, Swc2, TCFL1, vacuolar protein sorting 72, vacuolar protein sorting 72 homolog, YL-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VPS72 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- YL1 nuclear protein
- histone binding
- transcription regulator
- YL1 nuclear protein C-terminal domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cutaneous melanoma
- cutaneous melanoma cancer
regulates
- DNA endogenous promoter
- RNA polymerase II
- DNA promoter
role in cell
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleosomes
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VPS72 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- positive regulation of gene expression, epigenetic
- regulation of double-strand break repair
- positive regulation of transcription, DNA-dependent
- somatic stem cell maintenance
- regulation of transcription, DNA-dependent
- regulation of apoptotic process
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- NuA4 histone acetyltransferase complex
- nuclear speck
- macromolecular complex
- nucleosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- histone binding