IGFBP7 Gene Summary [Human]
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]
Details
| Type | Processed Transcript |
| Official Symbol | IGFBP7 |
| Official Name | insulin like growth factor binding protein 7 [Source:HGNC Symbol;Acc:HGNC:5476] |
| Ensembl ID | ENSG00000163453 |
| Bio databases IDs | |
| Aliases | insulin like growth factor binding protein 7 |
| Synonyms | AGM, FSTL2, IBP-7, IGFBP-7v, IGFBPRP1, insulin-like growth factor binding protein 7, MAC25, PROSTACYCLIN STIMULATING FACTOR, PSF, RAMSVPS, TAF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IGFBP7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- receptor agonist activity
- protein binding
- KAZAL_FS
- Immunoglobulin V-set domain
- transporter
Pathways
Biological processes and signaling networks where the IGFBP7 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- metastatic colorectal cancer
- survival
- aortic valve calcification
- rheumatoid arthritis
- heart failure
- colorectal cancer
- hemangioma
- angiomatosis
- tuberculosis
role in cell
- expression in
- migration
- proliferation
- adhesion
- differentiation
- colony formation
- apoptosis
- quantity
- morphology
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- nuclear fraction
- Cytoplasm
- cell surface
- endoplasmic reticulum lumen
- basal lamina
- microvilli
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IGFBP7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to retinoic acid
- regulation of cell growth
- negative regulation of cell proliferation
- cell adhesion
- cellular response to hormone stimulus
- regulation of steroid biosynthetic process
- regulation of signal transduction
- embryo implantation
- response to cortisol stimulus
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- insulin-like growth factor binding
- extracellular matrix structural constituent