Igfbp7 Gene Summary [Mouse]
Predicted to enable insulin-like growth factor binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within inner ear development. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Orthologous to human IGFBP7 (insulin like growth factor binding protein 7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Igfbp7 |
| Official Name | insulin-like growth factor binding protein 7 [Source:MGI Symbol;Acc:MGI:1352480] |
| Ensembl ID | ENSMUSG00000036256 |
| Bio databases IDs | |
| Aliases | insulin-like growth factor binding protein 7 |
| Synonyms | AGM, FSTL2, IBP-7, IGFBP-7v, IGFBPRP1, insulin-like growth factor binding protein 7, MAC25, PROSTACYCLIN STIMULATING FACTOR, PSF, RAMSVPS, TAF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Igfbp7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- receptor agonist activity
- protein binding
- KAZAL_FS
- Immunoglobulin V-set domain
- transporter
Pathways
Biological processes and signaling networks where the Igfbp7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- metastatic colorectal cancer
- survival
- aortic valve calcification
- rheumatoid arthritis
- heart failure
- colorectal cancer
- hemangioma
- angiomatosis
- tuberculosis
role in cell
- expression in
- migration
- proliferation
- adhesion
- differentiation
- colony formation
- apoptosis
- quantity
- morphology
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- nuclear fraction
- Cytoplasm
- cell surface
- endoplasmic reticulum lumen
- basal lamina
- microvilli
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Igfbp7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to retinoic acid
- regulation of cell growth
- negative regulation of cell proliferation
- cell adhesion
- cellular response to hormone stimulus
- regulation of steroid biosynthetic process
- regulation of signal transduction
- embryo implantation
- response to cortisol stimulus
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- insulin-like growth factor binding
- extracellular matrix structural constituent