PTGER3
PTGER3 Gene Summary
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Details
| Type | Protein Coding |
| Official Symbol | PTGER3 |
| Official Name | prostaglandin E receptor 3 [Source:HGNC Symbol;Acc:HGNC:9595] |
| Ensembl ID | ENSG00000050628 |
| Bio databases IDs | |
| Aliases | prostaglandin E receptor 3 |
| Synonyms | EP3,Ep3b,Ep3 gamma,EP3R,Ep3 γ,lnc003875,PGE2-R,Pgerep3,prostaglandin E receptor 3,prostaglandin E receptor 3 (subtype EP3),Ptgerep3,Rep3,rEP3a,rEP3b |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- intracellular loop
- prostaglandin E receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the PTGER3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CYP51A1
- IPO9
- REL
- UBTF
- PLEKHG4
- EVI5L
- CWC22
- PIK3CB
- prostaglandin E2
- PPP1R15B
disease
- hyperglycemia
- obesity
- pain
- weight gain
- diabetes mellitus
- primary open-angle glaucoma
- prostate cancer
- endometriosis
- chronic kidney disease
- open-angle glaucoma
regulated by
- beta-estradiol
- CNTF
- progesterone
- PRKCE
- prostaglandin E2
- medroxyprogesterone acetate
- aspirin
- KITLG
- MAPK15
- GW3965
regulates
- ADCY
- K+
- TYR
- cyclic AMP
- Ca2+
- RELA
- BAX
- BCL2
- ERK1/2
- LEP
role in cell
- expression in
- cell death
- apoptosis
- activation in
- synthesis in
- response
- size
- binding in
- activation
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- perinuclear region
- cellular membrane
- nuclear envelope
- neurites
- brush border
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PTGER3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- inflammatory response
- cell death
- G-protein coupled receptor signaling pathway
- intestine smooth muscle contraction
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
- positive regulation of fever generation
- negative regulation of gastric acid secretion
- elevation of cytosolic calcium ion concentration
CELLULAR COMPONENT
Where in the cell the gene product is active
- nuclear envelope
- membrane
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- prostaglandin E receptor activity