RPP14 Gene Summary [Human]
This gene encodes a subunit of ribonuclease P and has 3' to 5' exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene. [provided by RefSeq, May 2017]
Details
| Type | Protein Coding |
| Official Symbol | RPP14 |
| Official Name | ribonuclease P/MRP subunit p14 [Source:HGNC Symbol;Acc:HGNC:30327] |
| Ensembl ID | ENSG00000163684 |
| Bio databases IDs | |
| Aliases | ribonuclease P/MRP subunit p14 |
| Synonyms | 2610511E03Rik, LOC100044172, P14, ribonuclease P 14 subunit, ribonuclease P/MRP subunit p14 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPP14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rpp14/Pop5 family
- ribonuclease P
- enzyme
- protein binding
- RNA binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- dense fibrillar component
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RPP14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA 5'-leader removal
Cellular Component
Where in the cell the gene product is active
- multimeric ribonuclease P complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ribonuclease P activity
- protein binding
- ribonuclease P RNA binding