RPP25 Gene Summary [Human]
Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in centriolar satellite and nucleoplasm. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. Biomarker of autistic disorder. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RPP25 |
| Official Name | ribonuclease P and MRP subunit p25 [Source:HGNC Symbol;Acc:HGNC:30361] |
| Ensembl ID | ENSG00000178718 |
| Bio databases IDs | |
| Aliases | ribonuclease P and MRP subunit p25, RNase P protein subunit p25 |
| Synonyms | AI851155, ribonuclease P and MRP subunit p25, ribonuclease P/MRP 25 subunit |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPP25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribonuclease P
- enzyme
- protein binding
- Alba
- RNA binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RPP25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rRNA processing
- tRNA 5'-leader removal
Cellular Component
Where in the cell the gene product is active
- ribonuclease MRP complex
- centriolar satellite
- multimeric ribonuclease P complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ribonuclease P activity
- RNA binding
- protein binding
- ribonuclease P RNA binding