POP5 Gene Summary [Human]
Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in nucleolus. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | POP5 |
| Official Name | POP5 homolog, ribonuclease P/MRP subunit [Source:HGNC Symbol;Acc:HGNC:17689] |
| Ensembl ID | ENSG00000167272 |
| Bio databases IDs | |
| Aliases | POP5 homolog, ribonuclease P/MRP subunit |
| Synonyms | 1500019J17Rik, 2700077E03Rik, hPop5, HSPC004, POP5 homolog, ribonuclease P/MRP subunit, processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae), Rnasep3, RPP2, RPP20 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POP5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rpp14/Pop5 family
- ribonuclease MRP
- ribonuclease P
- enzyme
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POP5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rRNA processing
- tRNA 5'-leader removal
Cellular Component
Where in the cell the gene product is active
- ribonuclease MRP complex
- multimeric ribonuclease P complex
- nucleolus
- nucleolar ribonuclease P complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ribonuclease P activity
- protein binding
- ribonuclease P RNA binding