SUPT3H Gene Summary [Human]
Enables transcription coactivator activity. Involved in histone H3 acetylation and histone deubiquitination. Located in nucleoplasm. Part of SAGA complex and transcription factor TFTC complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | SUPT3H |
| Official Name | SPT3 homolog, SAGA and STAGA complex component [Source:HGNC Symbol;Acc:HGNC:11466] |
| Ensembl ID | ENSG00000196284 |
| Bio databases IDs | |
| Aliases | SPT3 homolog, SAGA and STAGA complex component |
| Synonyms | 2310066G22Rik, LOC683926, SPT3, SPT3 homolog, SAGA and STAGA complex component, SPT3L, SPT3, SAGA and STAGA complex component, Supt3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SUPT3H often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- transcription regulator
- transcription co-activator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- pain
- non-insulin-dependent diabetes mellitus
- diffuse idiopathic skeletal hyperostosis
- fracture of bone
- male pattern hair loss
- attention deficit hyperactivity disorder
- otosclerosis
regulates
- DNA promoter
- DNA endogenous promoter
- histone
- RNA polymerase II
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SUPT3H gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- regulation of RNA splicing
- regulation of DNA repair
- regulation of transcription, DNA-dependent
- transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFTC complex
- SAGA complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription coactivator activity
- protein heterodimerization activity